Management of Tourette's a.k.a. tics.

Aripiprazole is one of the best studied antipsychotics in Tourette's and this new RCT of the liquid form in 121 children adds to that.

However, it can cause other movement disorders; clonidine is a safer option.

Article here --> https://capmh.biomedcentral.com/articles/10.1186/s13034-024-00764-6

Randomized, double-blind, placebo-controlled trial of aripiprazole oral solution in children and adolescents with Tourette’s disorder - Child and Adolescent Psychiatry and Mental Health Background Aripiprazole is the most frequently recommended antipsychotic for the treatment of tics in children and adolescents with Tourette’s disorder. However, to date, a randomized controlled trial for aripiprazole oral solution has not been conducted despite being widely preferred by children. Therefore, we examined whether aripiprazole oral solution is effective for treating tics. Methods All patients received a flexible dose of aripiprazole oral solution ranges from 1 mg/mL: 2–20 mg with a starting dose of 2 mg. The target dose for patients weighing < 50 kg was 2, 5, and 10 mg/day, and that for patients weighing ≥ 50 kg was 5, 10, 15, and 20 mg/day. The primary efficacy endpoint was the mean change in the Yale Global Tic Severity Scale-total tic score YGTSS-TTS from baseline to week 8. Results Of the 121 patients enrolled, 59 patients 96.7% in the aripiprazole group and 53 patients 88.3% in the placebo group completed the study. The aripiprazole group showed significantly greater improvement. capmh.biomedcentral.com

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Dr. Rob