What works best for treatment-resistant depression?

New analysis lands on ECT, TMS, glutamatergics (ketamine, minocycline, cycloserine), and aripiprazole: 

Saelens, J., Gramser, A., Watzal, V., Zarate, C. A., Jr, Lanzenberger, R., & Kraus, C. (2024). Relative effectiveness of antidepressant treatments in treatment-resistant depression: A systematic review and network meta-analysis of randomized controlled trials. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology, 10.1038/s41386-024-02044-5. Advance online publication. https://doi.org/10.1038/s41386-024-02044-5

https://nam12.safelinks.protection.outlook.com/?url=https%3A%2F%2Fdoi.org%2F10.1038%2Fs41386-024-02044-5&data=05%7C02%7Cspanor%40westernu.edu%7C5a134b123da645adea8808dd33eb615f%7C25a6f4f8d912492a84df376754ba693e%7C0%7C0%7C638723808269754115%7CUnknown%7CTWFpbGZsb3d8eyJFbXB0eU1hcGkiOnRydWUsIlYiOiIwLjAuMDAwMCIsIlAiOiJXaW4zMiIsIkFOIjoiTWFpbCIsIldUIjoyfQ%3D%3D%7C0%7C%7C%7C&sdata=hU7xXFsSA4Bnk7A70UuoqN%2FdrlH7pJI%2F8Xy4urbu8Uk%3D&reserved=0

Relative effectiveness of antidepressant treatments in treatment-resistant depression: a systematic review and network meta-analysis of randomized controlled trials - Neuropsychopharmacology doi.org

There are many ways to parse the data, but most of these are backed by other analyses except perhaps minocycline.

Thank you

Dr. Rob