Tricyclic antidepressants

Updates on tricyclic antidepressants from a new meta-analysis of 103 trials:

All work equally well
High rates of side effects https://pubmed.ncbi.nlm.nih.gov/39093721/
I generally start with nortriptyline lowest risk of hypotension, but may use protriptyline because it is least sedating, or imipramine which has the best evidence for anxiety.

Thank you for reading

Dr. Rob

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