Irritable Bowel Syndrome a.k.a IBS

Low-dose amitriptyline (10-30mg) treated irritable bowel syndrome (IBS) in this large, well designed, 6 month RCT: 

https://pubmed.ncbi.nlm.nih.gov/39397570/

Low-dose titrated amitriptyline as second-line treatment for adults with irritable bowel syndrome in primary care: the ATLANTIS RCT - PubMed This award was funded by the National Institute for Health and Care Research (NIHR) Health Technology Assessment programme (NIHR award ref: 16/162/01) and is published in full in <i>Health Technology Assessment</i> Vol. 28, No. 66. See the NIHR Funding and Awards website for further award informatio … pubmed.ncbi.nlm.nih.gov

Caution: IBS is the #1 medical comorbidity in bipolar, and amitriptyine is the riskiest antidepressant there.

Thank you

Dr. Rob